阿昔洛韋 
acycloguanosine 
CAS 編號(hào)：59277-89-3 
包裝規(guī)格：暫無(wú)規(guī)格型號(hào) 
Packing: 25kg cardboard drum   
產(chǎn)品說(shuō)明： 性質(zhì)：白色結(jié)晶性粉末。無(wú)臭無(wú)味，
其鈉鹽溶于水。
標(biāo)準(zhǔn)：中國(guó)藥典2005版按無(wú)水物計(jì)算，含C8H11N5O3
得少于98.0％；溶液的澄清度與顏色應(yīng)符合規(guī)定；有關(guān)
物質(zhì)應(yīng)符合規(guī)定；鳥(niǎo)嘌呤應(yīng)符合規(guī)定；干燥失重不得過(guò)6.0％；
熾灼殘?jiān)坏眠^(guò)0.1％?；含重金屬不得過(guò)0.001％。
制法：減壓蒸去過(guò)量的乙酐，冷至0℃過(guò)濾，濾餅用乙醇和水洗，
干燥，得N，N′-二乙酰鳥(niǎo)嘌呤?；蛘啉B(niǎo)嘌呤三甲基硅烷化后，
再和2芐氧基乙氧基甲基氯反應(yīng)后，再去掉芐基得阿昔洛韋。
將乙酐、乙酸和對(duì)甲苯磺酸混合，冷至1O℃以下。鳥(niǎo)嘌呤和乙酐混合，
加入少量乙酸和乙酸鋅，攪拌回流。濾餅用氯仿洗滌，干燥后溶于40％
甲胺水溶液，攪拌回流。加入氯仿，過(guò)濾。冷卻，過(guò)濾，濾液減壓濃縮
至漿狀物，冷卻后用乙醇洗，過(guò)濾。濾餅用水重結(jié)晶，得阿昔洛韋。 　
以鳥(niǎo)嘌呤為原料。
用途：該品是嘌呤核苷衍生物，對(duì)DNA的合成有抑制作用，其抗皰疹病
毒活性比阿糖腺苷強(qiáng)160倍。臨床用于單純性皰疹病毒腦炎、皰疹病毒
角膜炎及外生殖器感染、艾滋病的水痘帶狀皰疹病毒感染和巨細(xì)胞病毒
感染，慢性乙型肝炎等。
acycloguanosine
CAS No. :59277-89-3
Package: No Specification
Packing: 25kg cardboard drum 
Specification: CP/EP6.0
Product Description: Nature: white crystalline powder. 
Odorless and tasteless, the sodium salt dissolved in water.
Standard: Chinese Pharmacopoeia 2005 edition by the anhydrous 
basis, may be less than 98.0% with C8H11N5O3; Clarity and color
 of the solution should meet the requirements; related materials
 should meet the requirements; guanine should meet the requirements;
 not over 6.0% Loss on drying; Chi Residue on Ignition shall not 
be over 0.1% ?; 0.001% heavy metals may not have.
For herpes simplex virus encephalitis, keratitis and genital herpes
 infection, AIDS, varicella zoster virus infection and cytomegalovirus
 infection, chronic hepatitis B and so on.